Role of enteric dysbiosis in the development of central obesity: A review

Abstract

The adipose tissue in a healthy individual is involved in many processes, such as controlling body temperature, energy storage and satiety. An average overweight person can have different fat deposited in target organs or specific body compartments. In the case of pot belly, the accumulation of these fats is in the belly. Central obesity (pot belly) is a result of complex interactions among genetic, environmental, dietary habits, and other lifestyle factors. The gut and enteric microbiota are essential to human health. Each is composed of trillions of bacteria, viruses, and fungi and Impact numerous physiological processes in humans, such as digestion, immune system regulation, metabolism, and even mental health. This depends on the makeup and balance of this microbiota. An increasing number of studies have investigated the connection between health issues like abdominal obesity and the formation of a "pot belly" and the gut microbiota in recent years. It is extremely concerning that this extra fat buildup in the abdomen region is associated with a higher risk of numerous health issues. To address these health issues and develop prevention and treatment strategies such as the use of prebiotics, probiotics, use of antibiotics, it is essential to comprehend the relationship between pot belly and the enteric microbiota. The aim of this review is to deepen our understanding on relationships between alterations in gut microbiota composition and the development of central obesity. Determine how dysbiosis may contribute to metabolic dysregulation, inflammation, and other factors associated with the accumulation of abdominal fat. Explore potential interventions aimed at modulating gut microbiota composition to mitigate central obesity risk. This may include dietary modifications, probiotic or prebiotic supplementation, fecal microbiota transplantation.