Review of: "Design and Molecular Screening of Various Compounds by Molecular Docking as BACE-1 Inhibitors"

Abstract

In this study, the authors use molecular docking to study the interaction of quercetin, myricetin, & baicalein, ferulic acid, and donepezil with the BACE-1 protein and found that these compounds exhibit binding affinity, showing that they can fit better in the active site of BACE-1.According to the authors, these findings represent a major breakthrough in Alzheimer's disease research.This paper appears to be interesting but needs a major revision.It cannot be accepted in its current form; therefore, further corrections are required following the comments listed below :1.In the introduction, I understand that the authors want to clarify the -amyloid hypothesis by using the colon; I would suggest the authors rewrite in their own words, removing the double colon in -amyloid hypothesis: The -amyloid is a by-product of the protein Amyloid Precursor Protein (APP), whose function is believed to be involved in neuronal degradation.