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article · International Immunopharmacology

RETRACTED: Ameliorative effects of vanillin against pentylenetetrazole-induced epilepsy and associated memory loss in mice: The role of Nrf2/HO-1/NQO1 and HMGB1/RAGE/TLR4/NFκB pathways

202422 citationsOpen accessZagazig University

Abstract

By increasing Nrf2/HO-1/NQO1 levels and downregulating the HMGB1/RAGE/TLR4/ NFκB pathway, Van offered protection in PTZ-kindled mice with subsequent attenuation in lipid peroxidation, upregulation in antioxidant enzyme activities, and reduction in inflammation and apoptosis.

Research topics

  • Biochemical and biochemical processes
  • Tryptophan and brain disorders
  • Neuroinflammation and Neurodegeneration Mechanisms

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DOI: 10.1016/j.intimp.2024.111657

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