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article · Biological Research

Renoprotective effect of a novel combination of 6-gingerol and metformin in high-fat diet/streptozotocin-induced diabetic nephropathy in rats via targeting miRNA-146a, miRNA-223, TLR4/TRAF6/NLRP3 inflammasome pathway and HIF-1α

202413 citationsOpen accessMansoura University

Abstract

6-Gingerol demonstrated a key protective role in DN by induction of miRNA-146a and miRNA-223 expression and inhibition of TLR4/TRAF6/NLRP3 inflammasome signaling. 6-Gingerol, a safe, affordable, and abundant natural compound, holds promise for use as an adjuvant therapy with metformin in diabetic patients to attenuate renal damage and stop the progression of DN.

Research topics

  • Ginger and Zingiberaceae research
  • Inflammatory mediators and NSAID effects
  • Peroxisome Proliferator-Activated Receptors

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DOI: 10.1186/s40659-024-00527-9

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