article · Scholars Journal of Medical Case Reports
Widal syndrome, or aspirin-exacerbated respiratory disease, links asthma, chronic rhinosinusitis with nasal polyps, and hypersensitivity to non-steroidal anti-inflammatory drugs. While respiratory symptoms are typical, cutaneous signs can also emerge after drug exposure. A clinical case details a 50-year-old woman with asthma and a surgical history for nasosinusal polyposis who experienced recurrent chronic urticaria alongside angioedema. Her skin symptoms intensified following the consumption of non-steroidal anti-inflammatory drugs. Identifying the combination of her respiratory conditions and medication sensitivity confirmed the diagnosis of Widal syndrome. Implementing a management strategy based on montelukast, up-dosed antihistamines, and the strict avoidance of non-steroidal anti-inflammatory medications resulted in sustained clinical improvement over a six-month observation period.
Widal syndrome can present with complex skin reactions alongside respiratory problems, complicating routine care. Recognising that recurrent urticaria and angioedema may stem from non-steroidal anti-inflammatory drug hypersensitivity helps clinicians make accurate diagnoses. The documented response demonstrates that combining leukotriene receptor antagonists, intensified antihistamine regimens, and allergen avoidance offers effective relief for patients experiencing refractory symptoms.
The abstract describes an individual clinical case using established medications and does not indicate an application pathway.
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Widal syndrome, also known as aspirin-exacerbated respiratory disease (AERD), is characterized by the association of asthma, chronic rhinosinusitis with nasal polyps, and hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs). Cutaneous manifestations may occur following NSAID exposure. We report the case of a 50-year-old woman with asthma and a history of surgery for nasosinusal polyposis who presented with recurrent chronic urticaria associated with angioedema and exacerbated by NSAID intake. The association of asthma, nasal polyposis, and NSAID hypersensitivity led to the diagnosis of Widal syndrome. Treatment with montelukast combined with up-dosed antihistamine therapy and NSAID avoidance resulted in sustained clinical improvement at 6 months.
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DOI: 10.36347/sjmcr.2026.v14i08.032
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