review · ACS Omega
Polymer-based biosensors offer a promising approach for early cancer detection by identifying specific biomarkers in biological samples. These diagnostic tools use functionalised natural or synthetic polymers to achieve high sensitivity, strong selectivity, and low manufacturing costs. Compared to conventional cancer detection techniques, polymer biosensing platforms provide key benefits such as non-invasive testing and real-time monitoring capabilities without sacrificing precision or reliability. Recent progress centres on optimising the design, fabrication, and operational performance of these devices, with specific strategies developed to tailor polymer properties for enhanced biosensing. Both natural and synthetic polymer materials play distinct roles in improving device functionality. By advancing these polymer systems, diagnostics can achieve more dependable detection of cancer markers, supporting earlier clinical intervention and better management of patient health.
Detecting cancer at an early stage greatly increases the likelihood of successful treatment and patient survival. Traditional diagnostic approaches can be invasive or slow, but polymer-based biosensors provide an accurate, low-cost method for real-time monitoring. This progress supports the development of simpler, faster testing tools that could make routine cancer screening more accessible and less burdensome for patients.
The technology targets diagnostic applications, specifically screening and monitoring tools for healthcare providers and clinical laboratories seeking rapid, non-invasive biomarker detection. While the low cost and real-time capabilities are attractive for commercial diagnostic devices, this work synthesises current design, fabrication, and polymer-tailoring approaches, indicating that the field remains in the research and development phase rather than near-market deployment.
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Early diagnosis of cancer can significantly contribute to improving therapeutic outcomes and enhancing survival rates for cancer patients. Polymer-based biosensors have emerged as a promising tool for cancer detection due to their high sensitivity, selectivity, and low cost. These biosensors utilize functionalized polymers in different parts of the body to detect cancer biomarkers in biological samples. This approach offers several advantages over traditional detection methods, including real-time monitoring and noninvasive detection while maintaining high sensitivity and accuracy. This review discusses recent advances in the development of polymer-based biosensors for cancer detection including their design, fabrication, and performance. The essential characteristics of biosensing devices are presented, along with examples for natural and synthetic polymers commonly utilized in biosensors. Furthermore, strategies employed to tailor polymers to improve biosensing applications and future perspectives for the application of polymer-based biosensors in cancer diagnosis are also highlighted. Integrating these advancements will illuminate the potential of polymer-based biosensors as transformative tools in the early detection and management of cancer.
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DOI: 10.1021/acsomega.4c10652
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