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article · International Journal of Dermatology

Reappraisal of psoriasis pathogenesis: the role of <scp>TEAD4</scp> expression in keratinocytes

20242 citationsMenoufia University

Abstract

TEAD4 expression was higher in lesional than nonlesional skin and absent in healthy skin, suggesting a role in psoriasis development. TEAD4 expression was also associated with severe and progressive psoriasis. This may be mediated by the downregulation of FOXP3 and dysfunction of Treg cells. TEAD4 could serve as a promising therapeutic target in psoriasis.

Research topics

  • Hippo pathway signaling and YAP/TAZ
  • Cell Adhesion Molecules Research
  • Cytokine Signaling Pathways and Interactions

Sustainable Development Goals

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DOI: 10.1111/ijd.17187

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