article · Frontiers in Immunology

Preclinical evaluation of Lactiplantibacillus plantarum as a probiotic alternative against multidrug-resistant avian pathogenic Escherichia coli in chickens

Hanem El-Sharkawy
Yamen Hegazy
Hussein Babiker
Ahmed M. Abdelsalam
Mohamed Marzok
Amin Tahoun

2025Open accessKafr el-Sheikh University

Abstract

<i>L. plantarum</i> ATS1 provides protective and immunomodulatory effects against APEC by supporting intestinal colonization, surviving in macrophages, and enhancing humoral immunity. These findings highlight its potential as a probiotic strategy to improve broiler health and reduce dependence on antibiotics.

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DOI: 10.3389/fimmu.2025.1640600

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