Potential role of PVP/poloxamer 407 nanofibers loaded with resveratrol nanocrystals in skin cancer therapy

Abstract

cytotoxicity assay compared NF-NC2 with NF-D, demonstrating NF-NC2's efficacy against squamous malignant cell viability. In the Ehrlich-induced animal model of skin cancer, mice treated with NF-NC2 showed the greatest alleviation of symptoms, as evidenced by reduced tumour growth and preserved healthy skin. Assessments of Ki-67 and tumour biomarkers demonstrated that NF-NC2 maintained levels comparable to those observed in healthy animals. It is concluded that selected resveratrol-loaded nanocrystals in nanofibers, NF-NC2, improved the resveratrol topical anti-skin cancer effect.