Potential pathogenesis of <i>Helicobacter pylori</i> strains from Cameroon: seroprevalence of 10 proteins involved in the pathogenesis of <i>Helicobacter pylori</i> -related gastro-duodenal diseases, measured using a new multiplex immunoassay among <i>Helicobacter pylori</i> IgM-positive dyspeptic patients

Abstract

BACKGROUND: infected patients. RESEARCH DESIGN AND METHODS: antigens were classified as antigens for colonization, chaperone systems, immunomodulatory factors and toxins/effectors delivery/T4SS-related support factors. RESULTS: CagA, VacA, FliD, HpaA, GroEL gGT, HtrA, HP0231, CtkA, and NapA proteins were present in 97.1, 77.2, 77.2, 73.2, 61, 34.2, 25.4, 18.8, 11.4, and 9.9%. Antigens involved in colonization, immune response, proteins chaperone, and toxins/effectors and T4SS-related support factors were detected in 81.9%, 19.8%, 70.5%, and 10.6%, respectively. Significant high sensitivity of virulence antigens was recorded among patients aged more than 20 years old, those from west region, male, blood group O, and overweight/obese patients. CONCLUSION: strains in our milieu have a strong ability to colonize the gastric mucosa, but a low carcinogenic potential due to the scarcity of the proteins modulating the detrimental effect of CagA/VacA proteins.