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article · Parasite Epidemiology and Control

Polymorphisms of the plasmodium falciparum dihydropteroate synthase gene among patients attending LEPI and ADLUCEM hospitals in the west region of Cameroon

2026Open accessUniversité de Dschang

Abstract

Background: ) gene in two health facilities in the Mbouda Health District, Cameroon. Methodology: to detect the A437G and A581G mutations, respectively. Results: = 0.001), with the highest prevalence among participants with primary education only (41.66%) and the lowest among those with no formal schooling (10.34%). The frequency of the A581G mutant allele was 67.60%, while that of A437G was 45.07%. The wild-type allele frequencies were 48.87% for A437G and 22.53% for A581G. Mixed alleles were observed only for A437G (1.40%). Conclusion: mutations associated with pyrimethamine resistance were not assessed, overall sulfadoxine-pyrimethamine efficacy cannot be conclusively determined.

Research topics

  • Biochemical and Molecular Research
  • Malaria Research and Control
  • Metabolism and Genetic Disorders

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DOI: 10.1016/j.parepi.2026.e00510

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