article · ACS Omega
A novel photoprobe, Tb–acetylacetone (Tb–ACAC) doped within a modified epoxy cellulose polymer immobilized with CA-125 monoclonal antibody, offers an accurate and highly selective method for early ovarian cancer (OC) diagnosis by detecting cancer antigen 125 (CA-125) in serum samples. This approach leverages quenching of the Tb–ACAC luminescence upon binding to CA-125. Characterization of the photoprobe film through UV–vis and fluorescence measurements confirmed the presence of Tb–ACAC within the polymer matrix. In aqueous solution (pH 6.8, λex = 365 nm), the characteristic emission band of Tb–ACAC at λem = 546.2 nm exhibited significant quenching upon CA-125 binding. This quenching effect enabled the sensitive and specific detection of CA-125 in diverse serum samples from OC patients, demonstrating the applicability, simplicity, and effectiveness of this novel approach.
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DOI: 10.1021/acsomega.4c01814
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