article · Drugs and Drug Candidates
This review article explores the historical and ongoing significance of natural products, particularly those derived from plants, as a source for drug discovery and development. Plants have long provided folk remedies and inspired new drug designs. With the demand for chemical diversification in drug screening, natural products are vital, especially given the vast unexplored global biodiversity. However, challenges exist, including identifying effective high-throughput screening bioassays, scaling up the supply of bioactive molecules, and sourcing plant materials. Overcoming these hurdles requires multi-disciplinary, national, and global partnerships. The article discusses current advancements and future strategies for discovering natural products for health and wellness, aiming to unify their therapeutic use worldwide to support future plant-derived drug discoveries.
This research highlights the enduring importance of plants as a source for new medicines, addressing the global need for diverse chemical compounds to combat various diseases. By identifying challenges and proposing collaborative solutions, it aims to accelerate the discovery and development of life-saving drugs from natural sources.
This work focuses on the foundational aspects of drug discovery, identifying natural products as a source for new therapeutic leads. It is early-stage research, enabling the identification of potential drug candidates. The insights could be valuable for pharmaceutical companies, biotechnology firms, and research organisations involved in drug development, by guiding strategies for sourcing and screening natural compounds.
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For thousands of years, nature has been a source of medical substances, and an astounding numeral of contemporary remedies have been identified from natural origins. Plants have long been used as folk herbal medicines to treat various disorders, and their different natural products have inspired the design, discovery, and development of new drugs. With the invention of recent molecular targets based on proteins, there is a growing need for fresh chemical diversification in screening. Natural products will play a vital part in supplying this need via the continuous exploration of global biodiversity, the majority of which remains unexplored. Even though drug discovery from medicinal plants remains an important source of novel therapeutic leads, various hurdles exist, including identifying and executing suitable high-throughput screening bioassays, scaling up the supply of bioactive molecules, and acquiring plant materials. Investigating these natural resources takes multi-disciplinary, nationwide, and global partnerships in design, synthesis, discovery, and drug development techniques. This review article discusses current advancements and future approaches for discovering natural items such as health- and wellness-promoting remedies. It also summarizes strategies to unify the therapeutic use of plant-derived natural products worldwide to support future drug discoveries derived from plant sources.
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DOI: 10.3390/ddc3010011
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