Phytochemical profiling and multi-target pharmacological evaluation of Symphyotrichum squamatum unveils its potential as a source of antidiabetic and anti-inflammatory agents

Abstract

Introduction: aerial parts to assess its potential as a valuable source of natural therapeutic agents. The research focused on isolating and identifying bioactive compounds and evaluating their antioxidant, cytotoxic, antidiabetic, and anti-inflammatory effects. Method: Chromatographic purification, LC/MS, total flavonoids, total phenolics, molecular docking and different pharmacological activity were used in this study to identify qualitatively and qualitatively the active compounds in extract and its activities. Results: = 137.51 μg/mL). To explain these bioactivities, molecular docking studies were performed, revealing that the essential compounds, namely Kaempferol-3,7-diglucopyranoside and dicaffeoylquinic acids, form stable, high-affinity interactions with the reactive sites of α-amylase, α-glucosidase, and COX enzymes. Discussion: as a promising candidate for further development in the management of diabetes and inflammation.