article · Natural Product Research
Characterising the chemical composition of <i>Halogeton sativus</i> (L.) Moq. essential oil and its AcOEt (HSAE) and <i>n</i>-BuOH (HSBE) fractions aimed to evaluate their anti-inflammatory, antioxidant, and photoprotective properties. The main volatile components were tetracosane (14.55%), pentacosane (18.09%), and hexahydrofarnesylacetone (46.45%). Key phenolic constituents included gentisic, salicylic, chlorogenic, caffeic, and <i>p</i>-coumaric acids, with quercetin being the predominant compound in HSAE (33.62 mg/g). Antioxidant tests (DPPH•, ABTS<sup>•+</sup>, FRAP, and phenanthroline) indicated that HSAE demonstrated higher capacity (IC<sub>50</sub> = 7.90 ± 0.15 μg/mL, IC<sub>50</sub> = 13.36 ± 0.01 μg/mL, A<sub>0.5</sub> = 16.14 ± 0.09 μg/mL, and A<sub>0.5</sub> = 16.14 ± 0.09 μg/mL, respectively). Both HSBE and HSAE exhibited photoprotective efficacy with an SPF value around 33.9. Their anti-inflammatory potential was significant, with IC<sub>50</sub> values of 35.16 ± 0.93 and 78.15 ± 0.13 µg/mL, respectively. These findings suggest the possible applications of <i>H. sativus</i> for reducing inflammation, oxidative stress, and UV damage protection.
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DOI: 10.1080/14786419.2026.2649928
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