article · PLoS neglected tropical diseases

Persistent transmission of soil-transmitted helminths despite 16 years of uninterrupted Mebendazole- and ivermectin-based preventive chemotherapy in the Lomie Health District (East Region, Cameroon): The emergency of complementary control strategies

Arnauld Efon-Ekangouo
Verner N. Orish
Virtue Fiawokome De-Gaulle
Hugues C. Nana-Djeunga
Linda Djune-Yemeli
Martine Augusta Flore Tsasse
Laetitia Mbakam
Yannick Niamsi Emalio
Michèle L Simo-Simo
Joseph Kamgno

2024Open accessUniversité de Yaoundé I

Abstract

The persistent high prevalence and intensity of STH infection despite 16 years of mebendazole-based PCT and expected collateral impact of ivermectin mass distribution, points to plausible implementation gaps, poor compliance to WASH or sub-optimal efficacy of the anthelminthics used. This study highlights the need to further assess the cause of the persistent high prevalence and implement context-adapted control measures in order to curb STH transmission.

Research topics

Parasites and Host Interactions
Helminth infection and control
Parasite Biology and Host Interactions

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DOI: 10.1371/journal.pntd.0012508

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