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letter · JAMA Ophthalmology

Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent

20243 citationsOpen accessUniversity of Ibadan

Abstract

In this cross-sectional study, despite some improvements in OR-based risk stratification using the Gharahkhani PRSs, Han PRSs, and Craig PRSs, consistently lower improvements in AUROC and R2 for African-ancestry compared with European-ancestry groups highlight the need for risk prediction models tailored to diverse populations.

Research topics

  • Glaucoma and retinal disorders
  • Retinal Diseases and Treatments
  • Retinal Imaging and Analysis

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DOI: 10.1001/jamaophthalmol.2024.4784

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