Pentazocine As Adjuvant To Lidocaine Epidural Anaesthesia In Goats

Abstract

The study evaluated the effect of pentazocine on lidocaine for epidural anaesthesia in goats. Four adult intact male West African Dwarf goats weighing 7.3 ± 0.5 kg (Means ± SD) were subjected to two sets of experiments in a crossover design at an interval of one week for drug washout. The experiments involved the epidural administration of lidocaine hydrochloride at 2 mg/kg and the epidural administration of lidocaine hydrochloride at 1 mg/kg combined with pentazocine at 0.5 mg/kg. Selected anaesthetic indices were calculated, and vital signs - heart rate, respiratory rate, and rectal temperature were taken before drug administration and at 10-minute intervals after that. Onsets of drug action and analgesia with lidocaine (1.67± 1.2 minutes; 3.7±0.6 minutes) were longer than with lidocaine- pentazocine (1.0± 0.1 minutes; 3.0± 1.0 minutes). Duration of analgesia with lidocaine (52.0 ± 6.9 minutes) was significantly longer (p = 0.0021) than with lidocainepentazocine (29.0 ±5.7 minutes). Duration of recumbency with lidocaine (55.0 ± 11.9 minutes) was also significantly longer (p = 0.0001) than with lidocaine - pentazocine (34.0 ± 1.2 minutes). There were no significant differences (p ≥ 0.05) in the physiological parameters of the goats following the two treatments and were all within reference ranges. In conclusion, epidural administration of lidocaine combined with pentazocine as an adjuvant produced a faster onset of analgesia than lidocaine alone but a shorter duration of analgesia and recumbency than lidocaine alone and did not enhance analgesia at the dosages employed for both drugs combination in this study.