article · Clinical Infectious Diseases

Patterns of HIV-1 Viral Load Suppression and Drug Resistance During the Dolutegravir Transition: A Population-based Longitudinal Study

Marc Martín
Robert Ssekubugu
George MacIntyre-Cockett
Caitlin E. Kennedy
Ronald M. Galiwango
Nicholas Grayson
Alexandra Blenkinsop
Oliver Ratmann
Joseph Kagaayi
Michelle Moffa
Sikhulile Moyo
Godfrey Kigozi
Steven James Reynolds
Lucie Abeler-Dorner
Oliver Laeyendecker
Aaron A R Tobian
David Bonsall
Rajeev Gupta
Thomas C Quinn
Fred Nalugoda
Gertrude Nakigozi
Christophe Fraser
M Kate Grabowski

2026Open accessMakerere University

Abstract

Viral suppression increased during the DTG-transition with minimal emerging intermediate/high-level resistance. Falling resistance among treatment-experienced PLHIV underscores the role of ART adherence in reducing viremia. The emergence of inS153Y justifies continued surveillance.

Research topics

HIV/AIDS drug development and treatment
HIV Research and Treatment
HIV-related health complications and treatments

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1093/cid/ciag161

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