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article · The Journal of Infectious Diseases

Patterns and Cofactors of Polyfunctional Mycobacteria-Specific T-Cell Response Restoration Following 6-Month Antiretroviral Treatment in Children With HIV

20241 citationOpen accessUniversity of Nairobi

Abstract

Despite increases in Th1 cytokine production, deficits in mycobacteria-specific CD4 cells persisted 6 months after ART, with higher deficits in older CHIV with more immunosuppression, higher immune activation, and lower proportion of naive CD4 cells. These findings may explain persistent TB risk during early ART among CHIV and identify those at highest risk.

Research topics

  • HIV Research and Treatment
  • Immune Cell Function and Interaction
  • Tuberculosis Research and Epidemiology

Sustainable Development Goals

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DOI: 10.1093/infdis/jiae630

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