Oxidative Stress and Pregnancy-induced Hypertension: Antioxidant Solutions

Abstract

Pregnancy-induced hypertension (PIH) is a significant complication of pregnancy, contributing to adverse maternal and fetal outcomes. Recent research has illuminated the role of oxidative stress in the pathogenesis of PIH, characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses. This review examines the mechanisms by which oxidative stress contributes to endothelial dysfunction, increased vascular resistance, and systemic inflammation in the context of PIH. By elucidating these mechanisms, the review highlights the critical need for effective strategies to mitigate oxidative stress during pregnancy. Antioxidants have emerged as potential therapeutic agents for managing oxidative stress and preventing PIH. Various antioxidants, including vitamins C and E, omega-3 fatty acids, and coenzyme Q10, have shown p.romise in reducing oxidative damage and improving vascular health during pregnancy. Clinical trials have suggested that supplementation with these antioxidants may enhance endothelial function and lower blood pressure in at-risk pregnant women, thereby decreasing the incidence of PIH and related complications. Keywords: oxidative stress, pregnancy-induced hypertension, antioxidants, endothelial dysfunction, maternal health