Outcomes of acute myeloid leukemia patients in Assiut University Hospital

Abstract

Background About 80% of adult leukemia cases are diagnosed as acute myeloid leukemia (AML). This condition is characterized by the failure of erythropoiesis and the destruction of bone marrow. It is brought on by the clonal development of immature ‘blast cells’ in the peripheral blood and bone marrow. The success rate of treatment has increased by 15% for patients over the age of 60 as a direct result of recent recommendations, while it has increased by 40% for people younger than 60. The older population nevertheless has a dismal outlook, notwithstanding improvements in therapy regimens. Materials and methods This study was an observational prospective study. Targeted to evaluate the overall survival, rate of relapse, and complete remission among AML patients, in addition to the estimation of the percentage of refractory and relapsed AML cases on 50 newly diagnosed AML patients who were admitted to the Clinical Hematology Unit, Internal Medicine Department, Assiut University Hospital in 2 years duration. Results The study revealed that higher leukemia risk, patient response, and higher total leucocytic count were significant predictors for death among AML patients, meanwhile, patients’ age, sex, smoking status, and laboratory data, other than the total leucocytic count, show no effect on mortality rate among the studied cases. Conclusion Survival rate was higher in patients with lower leukemia risk and those with good prognosis.