article · Drug Design Development and Therapy

Novel Pyrazole-3-Cyano-2-Pyridinone Hybrids as Multitarget Anti-Inflammatory Agents: Synthesis, Computational Modeling, and Biological Evaluation

Bahgat R. M. Hussein
Heba A. Hofny
Hossameldin A. Aziz
Omar Alshazly
Stefan Bräse
Zuhier Awan
Aliaa M. Mohassab
Elsayed Mahmoud
Ibrahim Salem
Tarek Ibrahim
Mamdouh Mohamed

2026Open accessZagazig University

Abstract

The synthesized pyrazole/3-cyano-2-pyridinone hybrids demonstrated promising multi-target anti-inflammatory activity with favorable safety and pharmacokinetic profiles, highlighting their potential as lead candidates for further development.

Research topics

Synthesis and biological activity
Synthesis and Reactivity of Heterocycles
Ferrocene Chemistry and Applications

Read the original research

This page summarises published work. The authoritative version sits with the publisher.

View on publisher site Record on OpenAlex

DOI: 10.2147/dddt.s570813

Is something wrong with this record? Report it or request removal.

Discussion

Discuss this research

Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.

No discussion yet. Open the first thread.

New to MARATTO™? Create a free account.