book chapter · Advances in medical diagnosis, treatment, and care (AMDTC) book series
Parkinson's disease (PD) is a multisystem disorder considered the second most common neurodegenerative disease worldwide of which neuroprotective therapies are not yet available. PD is known mainly by its cardinal motor symptoms which are believed to be associated with dopamine deficiency in the nigrostriatal pathway as a result of DAergic neurons degeneration in the substantia nigra pars compacta of the midbrain. However, other brain structures degenerate (non-dopaminergic abnormalities) in PD resulting in other symptoms known as non-motor symptoms (NMS). NMS and non-DAergic abnormalities are sometimes present before diagnosis and almost inevitably emerge with the disease progression. Hence, they might play a tremendously important role in the management and sometimes even the diagnosis of PD. This chapter will provide an overview on the neuropathobiology of NMS in PD.
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DOI: 10.4018/978-1-6684-5156-4.ch003
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