Newly Designed 3 <i>d</i> ‐Metal(II) Complexes From Thiadiazole‐Carboxamide Ligand With Potential Antimicrobial, Anticancer, and DNA‐Reactivity

Abstract

A thiadiazole-carboxamide derivative (HLtos) is complexed to three 3d-metals (Co(II), Cu(II), and Ni(II) ions) in equal amounts, affording three new complexes (CoLtosCl.2H₂O, CuLtosNO₃, and NiLtosNO₃), respectively. The biological reactivity of the new compounds is demonstrated versus the growing development of human cancer cell lines and the microbial series, emphasizing the significant efficacy of the central metal influence in CoLtosCl.2H₂O, CuLtosNO₃, and NiLtosNO₃ in comparison to HLtos. They are tested through their ability to interact with DNA (deoxyribonucleic acid) using spectrophotometric/viscometric methods. The current compounds, as inhibitors, show effective antiproliferative action on the targeted microorganisms and tumor growth. Incorporation of Cu²⁺ and Co²⁺ ions in the complex amplified the anti-migration activity in the breast cancer cell line. Gibbs free energy and binding constant are applied to elucidate the interaction modes of HLtos, CoLtosCl.2H₂O, CuLtosNO₃, and NiLtosNO₃ with DNA. The influence of the metal ions in the complexing prodrugs enhanced their biochemical efficacy compared to HLtos. This study contributes to the rapidly developing field of metallo-prodrugs, which holds growing promise for cancer and infection therapy.