article · Marine Drugs
We reported three new members of the theonellapeptolide family from theonellapeptolide II series, namely theonellapeptolides IIb (<b>1</b>), IIa (<b>2</b>), IIc (<b>3</b>), and three known members-IId (<b>4</b>), IIe (<b>5</b>), and Id (<b>6</b>)-from Kodingarengan marine sponge <i>Theonella swinhoei</i> collected in Makassar, Indonesia. The structures of tridecadepsipeptides <b>1</b>-<b>3</b>, including the absolute configurations of their amino acids, were determined by the integrated NMR and tandem MS analyses followed by Marfey's analysis. To the best of our knowledge, <b>1</b> and <b>2</b> are the first theonellapeptolide-type compounds to have a valine residue with <sub>D</sub> configuration at residue position 6. The isolated theonellapeptolide-type compounds <b>1</b>-<b>6</b> showed selective cytotoxic activity against human pancreatic MIA PaCa-2 cancer cells in a nutrient-deprived medium. Among them, the most potent preferential cytotoxicity was observed in new theonellapeptolide IIc (<b>3</b>) and known IId (<b>4</b>), IIe (<b>5</b>), and Id (<b>6</b>).
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.3390/md20110661
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
