article · RSC Advances

New isoxazole-based heterocyclic hybrids with dual antimicrobial and antioxidant bioactivity: integrated synthesis, <i>in vitro</i> assessment, and computational exploration

Aziz Arzine
Reem M. Aljowaie
Asmae Nakkabi
Soumia Ait Assou
Mohammed El Hassouni
John P. Giesy
Lamiae El Bouamri
Mourad A. M. Aboul-Soud
Samir Chtita
Mohammed Chalkha
Mohamed El Yazidi

20261 citationOpen accessUniversité Moulay Ismail de Meknes

Abstract

predictions of Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADME-Tox) analysis predicted 5d to possess an optimal profile, with high gastrointestinal absorption and minimal toxicity, highlighting it as the lead candidate for the development of broad-spectrum antimicrobial drugs.

Research topics

Synthesis and biological activity
Multicomponent Synthesis of Heterocycles
Synthesis of heterocyclic compounds

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DOI: 10.1039/d6ra01005a

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