Netrin-1 and 8-Hydroxy-2-Deoxyguanosine as Predictor Biomarkers for Diabetic Nephropathy in Type 2 Diabetes Mellitus

Abstract

Background: Diabetic nephropathy (DN) is a significant problem for medicine. The purpose of the study was to investigate whether or not high blood levels of 8-Hydroxy-2-Deoxyguanosine (8-OHdG) and Netrin-1 may accurately predict diabetic nephropathy.Methods: In this research, there were a total of 60 patients with type 2 diabetes mellitus (T2DM), and they were divided into three groups based on the ratio of their urine albumin to creatinine: 30 patients with T2DM who did not have DN, 30 patients with T2DM who did have DN, and 30 healthy controls. All of the individuals had their serum levels of Netrin-1, 8-OHdG, creatinine, glycosylated hemoglobin, and eGFR tested. Additionally, their fasting blood glucose, lipid prolife, and glycosylated hemoglobin were evaluated.Results: In patients with type 2 diabetes who also had DN, the level of Netrin-1 was found to be much lower than in patients with type 2 diabetes who did not have DN. However, there was no statistically significant difference between these two groups and the control group. There was no statistically significant difference in the levels of 8-OHdG between the control group and the T2DM patients with or without DN.Conclusion: According to the findings of our research, neither blood levels of Netrin-1 nor serum levels of 8-OHdG were substantially related with diabetic nephropathy.