Natural Product-Based Therapies: Exploring the Potential of Ocimum gratissimum and Vitamin C Combination against Vibrio cholerae Infections

Abstract

The emergence of multi-drug resistant Vibrio species has become a significant global health concern, particularly in developing countries. Research has consistently shown that these bacteria possess plasmid-encoded genes that confer resistance to multiple antibiotics, complicating treatment options and posing a substantial threat to public health. This study investigates the antibacterial properties of Ocimum gratissimum (OG) extract against multi-drug resistant Vibrio species, a significant concern in developing countries. The research aimed to evaluate the effect of OG extract on various Vibrio strains isolated from stream samples. The study identified three Vibrio cholerae strains (C6123, E7919, and R1995) in the samples, with R1995 being the most prevalent. Quantitative analysis revealed the presence of various phytochemicals in OG, including alkaloids, steroids, and flavonoids. The extract demonstrated significant antibacterial activity against the Vibrio strains, particularly when combined with vitamin C. The results suggest that OG extract, especially when combined with vitamin C, exhibits potent antibacterial properties against Vibrio species. This finding has implications for the development of alternative treatments against multi-drug resistant bacterial infections.