review · Biomedicines
This review addresses the critical global health threat posed by widespread antibiotic resistance, particularly the emergence of multidrug-resistant (MDR) microorganisms and their ability to form highly resistant biofilms. The lack of new antimicrobial compounds has driven the search for innovative solutions. Nanotechnology is highlighted as a promising approach, offering novel strategies for treating and preventing biofilm formation and MDR infections. Nanomaterial-based therapeutics are explored for their potential to overcome acquired drug resistance mechanisms. The review examines the development and antibacterial mechanisms of nanoparticles, comparing free antibiotics with nanoantibiotics, and discusses their synergistic effects against various bacterial forms. It also considers the strengths and limitations of nanotechnology in combating bacterial infections.
Combating antibiotic resistance is crucial for global public health, as it leads to millions of deaths annually. This research highlights how nanotechnology could provide innovative solutions to overcome drug-resistant bacteria and biofilms, offering hope for more effective treatments where conventional antibiotics fail.
This review identifies nanotechnology as a promising area for developing novel antimicrobial therapeutics. Potential applications include new treatments for multidrug-resistant bacterial infections and biofilm-related diseases. The target users would be healthcare providers and pharmaceutical companies. As a comprehensive review of current advances and future perspectives, this work represents early-stage research, laying conceptual groundwork for future product development rather than presenting a near-market solution.
AI-generated from the published abstract. Always read the original work before citing.
The wide spread of antibiotic resistance has been alarming in recent years and poses a serious global hazard to public health as it leads to millions of deaths all over the world. The wide spread of resistance and sharing resistance genes between different types of bacteria led to emergence of multidrug resistant (MDR) microorganisms. This problem is exacerbated when microorganisms create biofilms, which can boost bacterial resistance by up to 1000-fold and increase the emergence of MDR infections. The absence of novel and potent antimicrobial compounds is linked to the rise of multidrug resistance. This has sparked international efforts to develop new and improved antimicrobial agents as well as innovative and efficient techniques for antibiotic administration and targeting. There is an evolution in nanotechnology in recent years in treatment and prevention of the biofilm formation and MDR infection. The development of nanomaterial-based therapeutics, which could overcome current pathways linked to acquired drug resistance, is a hopeful strategy for treating difficult-to-treat bacterial infections. Additionally, nanoparticles' distinct size and physical characteristics enable them to target biofilms and treat resistant pathogens. This review highlights the current advances in nanotechnology to combat MDR and biofilm infection. In addition, it provides insight on development and mechanisms of antibiotic resistance, spread of MDR and XDR infection, and development of nanoparticles and mechanisms of their antibacterial activity. Moreover, this review considers the difference between free antibiotics and nanoantibiotics, and the synergistic effect of nanoantibiotics to combat planktonic bacteria, intracellular bacteria and biofilm. Finally, we will discuss the strength and limitations of the application of nanotechnology against bacterial infection and future perspectives.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.3390/biomedicines11020413
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
