article · ChemistrySelect
Nanodiamonds present useful opportunities across dental medicine, including tissue regeneration, gene therapy, and targeted drug delivery. Their nanometre size, fluorescence, and selectivity for specific cells make them versatile tools for therapeutic and restorative tasks. In dental practice, they can reinforce polymers, deliver medications to treat infections or oral cancer, and serve as antibacterial or bioactive coatings on dental implants. Despite these capabilities, existing research on the biological compatibility of nanodiamonds remains scarce and insufficient. Comprehensive studies are necessary to evaluate how these materials interact safely with living tissues before clinical implementation can occur. Overall, nanodiamonds hold potential to become everyday materials in dental practice within the next decade once safety and biological compatibility requirements are properly established.
Nanodiamonds could improve dental healthcare by strengthening dental materials, preventing implant infections, and delivering precise treatments for conditions like oral cancer. However, before patients can benefit from these advanced materials, researchers must carry out thorough assessments to confirm that they are completely safe and compatible with human oral tissues.
The primary applications lie in dental therapeutics, implantology, and restorative materials, relevant to dental material manufacturers and oral healthcare practitioners. The technology remains at an early research stage, as routine use relies on resolving significant gaps in biological compatibility data before clinical testing and daily use can emerge over the coming decade.
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Abstract Nanodiamonds (NDs) are utilized for various purposes in dentistry, such as tissue regeneration, gene therapy, and medication delivery. Despite the examination of their potential for dental uses, there is currently no published review summarizing the conducted investigations. Additional investigations are required to comprehend the biological compatibility of NDs in dentistry. NDs have been proven effective for a variety of applications in dentistry because of unique qualities such as target cell selectivity, nanometer size, and fluorescence. Nanodiamonds find various applications in dentistry, encompassing roles in directed tissue regeneration, reinforcing polymers, and administering medications for treating infections and cancer. Researchers have also suggested the potential use of nanodiamonds as coatings for antibacterial or bioactive dental implants. Nevertheless, investigations on their biological compatibility have been scarce and insufficient so far, necessitating significantly further studies to envision the potential use of NDs in dentistry. It is believed that within the ten years to come, these emerging substances will discover several kinds of daily usage in dental practice.
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DOI: 10.1002/slct.202401328
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