Multifocal Presentations of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): A Case Series From a District General Hospital in South East England

Abstract

This case series describes five patients with diverse clinical presentations of myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelinating disease. MOG antibody-associated disease (MOGAD) is an autoimmune inflammatory disorder of the central nervous system (CNS), distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4 Ab+ NMOSD). Our cases highlight the varied manifestations, diagnostic challenges, and treatment responses among patients with MOGAD, emphasizing the importance of early diagnosis and appropriate management to prevent relapses and long-term disability.