article · Journal of Materials Research and Technology
Electrospun nanofibrous scaffolds were created using cellulose acetate encapsulated with hydroxyapatite modified by varying amounts of copper ions. Examination of the scaffold morphology revealed non-oriented fibrous networks with fibre diameters ranging between 0.6 and 6.9 micrometres, alongside surface roughness valley depths from 113.6 to 183.9 nanometres depending on copper levels. Mechanical evaluations demonstrated a minor improvement in material toughness with increased copper addition. Antibacterial tests showed clear inhibition against both Escherichia coli and Staphylococcus aureus, with the largest zones of inhibition achieved at the highest copper concentration. In laboratory cell cultures, human fibroblast lines displayed strong attachment, proliferation, and growth when seeded onto the composite nanofibrous matrices, indicating that integrating modified ceramics into cellulose acetate webs produces biomaterials suited for wound management.
Effective wound management relies on advanced dressings that defend healing tissue from bacterial contamination while simultaneously encouraging cellular repair. Combining biopolymers with copper-bearing ceramic particles delivers a dual-action scaffold that curbs common infection-causing bacteria and provides a biocompatible matrix for skin cells to populate, which is vital for developing high-performance skin regeneration therapies.
This work could inform the development of advanced wound dressings for medical device manufacturers and healthcare providers treating complex skin injuries. The material pairs structural support with intrinsic antimicrobial activity. Because evaluations remain restricted to laboratory material testing, bacterial culture assays, and in vitro fibroblast studies, the technology is at an early research stage and will require animal models and clinical validation prior to market entry.
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Accelerating and improving the healing quality of wounded injuries required the development of new strategies for fully functional regeneration of skin tissues. In this work, electrospun nanofibrous scaffolds based on cellulose acetate (CA) encapsulated with modified hydroxyapatite (HAP) with different contents of Cu ions. It was shown from morphological features that prepared webs were formed in a non-oriented network with diameters around 1.4–6.9, 1.3–6.3, 0.6–3.1, 0.79–3.7, and 0.8–3.9 μm for [email protected], [email protected], [email protected], [email protected], and [email protected], respectively. The maximum roughness valley depth (Rv) was varied from 113.6 nm to 183.9 nm for the lowest and the highest Cu contributions. The mechanical properties were also investigated and showed that toughness was enhanced slightly from 3.2 ± 0.3 to 3.3 ± 0.4 MJ/m3 for [email protected] and [email protected], respectively. Furthermore, the antibacterial behavior against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were tested, whereas the highest inhibition zones reached 6.3 ± 1.5 and 6.5 ± 1.1 mm for the highest addition Cu. Finally, human fibroblasts cell lines were cultivated in-vitro through the nanofibrous scaffold, and cells showed a high degree of response with proliferation and growing behaviors upon the compositional modification. Hence, tailoring of good dressings might be developed via nanofibrous scaffolds containing modified ceramics.
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DOI: 10.1016/j.jmrt.2020.09.094
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