article · RSC Advances
2-Aryloxyquinolines are well known for various biological activities. In this report, we have developed a novel protocol for introducing an acetoxy functional group on the aryl sp<sup>2</sup> carbon of 2-aryloxyquinoline-3-carbaldehyde using a palladium catalyst for the first time. Interestingly, this C-H acetoxylation reaction is highly chemo- and site-selective. By modifying the reaction conditions, mono or di <i>ortho</i>-C-H acetoxylation products have been synthesized selectively with good yields and with good functional group tolerance.
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DOI: 10.1039/d4ra01289e
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