article · Pharmaceuticals
Polysaccharides isolated from the red marine alga Alsidium corallinum are hetero-sulfated-anionic compounds composed of carbohydrates, sulfate groups, and uronic acids. Laboratory evaluations demonstrate that these algal extracts possess notable antioxidant and antimicrobial capacities. When tested in vivo, oral administration of the polysaccharides helped counter liver impairment induced by the fungicide tebuconazole in adult male rats. Treatment improved blood lipid markers, including total cholesterol, triglycerides, and lipoproteins, alongside reductions in liver enzymes such as alanine aminotransferase and aspartate aminotransferase. The intervention also curbed lipid peroxidation and protein oxidation, modulated lipid metabolism enzymes, enhanced overall antioxidant status, and enabled partial repair of damaged liver tissue. Furthermore, computational modeling indicated that algal monosaccharides bind key target receptors with favorable affinities, reinforcing the observed hypolipidemic, antimicrobial, and antioxidant properties.
Exposure to agricultural chemicals such as fungicides can cause significant liver damage and disrupt metabolic health through oxidative stress. Identifying natural bioactive compounds from marine sources offers a potential route to develop protective therapies. Demonstrating that red seaweed extracts can alleviate pesticide-induced organ toxicity and improve cholesterol balances highlights the value of marine biodiversity for therapeutic research.
This research is at an early stage, based on computational modelling, in vitro assays, and an animal model. The findings could eventually enable the development of pharmaceutical therapies or dietary supplements targeting liver diseases and oxidative metabolic disorders. Potential end users include pharmaceutical and nutraceutical manufacturers seeking marine-derived active ingredients, though extensive clinical development and formulation testing remain necessary before practical commercial application.
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Sulfated polysaccharides from seaweed are highly active natural substances with valuable applications. In the present paper, attempts have been made to discuss the physicochemical and structural features of polysaccharides isolated from red marine alga Alsidium corallinum (ACPs) and their protective effect in hepatic impairments induced by tebuconazole (TEB) in male adult rats. Structural features were determined using high-performance liquid chromatography, Fourier-transformed infrared, and solid-state 1H and 13C-Nuclear magnetic resonance analysis. ACPs are found to be hetero-sulfated-anionic polysaccharides that contain carbohydrates, sulfate groups, and uronic acids. In vitro biological activities suggested the effective antioxidant and antimicrobial capacities of ACPs. For antioxidant testing in vivo, the biochemical analysis and plasma profiles displayed that oral administration of ACPs could mitigate blood lipid indicators, including total cholesterol, triglyceride, low and high-density lipoprotein cholesterol, and bilirubin. Liver function indexes involving alanine aminotransferase and aspartate aminotransferase showed that ACPs possessed prominent antioxidant activities. Additionally, the intervention of ACPs potentially inhibited lipid peroxidation, protein oxidation, key enzymes of lipid metabolism (<0.001), and improved antioxidant status (<0.05). Histomorphological observation confirmed that ACPs intervention could partially repair liver injuries caused by TEB. The computational results showed that A. corallinum monosaccharides bound 1JIJ, 1HD2, and 1WL4 receptors with acceptable affinities, which, together with deep embedding and molecular interactions, support the antioxidant, antimicrobial, and hypolipidemic outlined effects in the in vitro and in vivo findings. Given their prominent antioxidant effects, ACPs are promising candidates for liver diseases and must be considered in pharmaceutical applications.
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DOI: 10.3390/ph16091305
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