Microneedle of Drug Delivery Systems

Abstract

Over the past few years, there has been significant interest in a developing transdermal delivery technology due to its ability to effectively deliver therapeutic and cosmeceutical products for various purposes. These applications include vaccines, drugs, and biomolecules aimed at addressing skin-related issues. One major advantage of transdermal administration is its ability to bypass the initial metabolic breakdown of the drug and facilitate sustained release. However, the stratum corneum acts as a barrier, limiting drug delivery. To overcome this challenge, microneedles (MNs) have emerged as a painless, minimally invasive, and user-friendly transdermal drug delivery system, offering high drug bioavailability. In recent years, various types of MNs have been developed using innovative production techniques. These MNs can be classified morphologically as solid, coated, dissolved, or hollow, depending on the specific transdermal drug delivery method employed, namely “poke and patch,” “coat and poke,” “poke and release,” and “poke and flow,” respectively.