Micro-RNA in a Sample of Egyptian Patients with Incidental Cerebral Small Vessel Disease

Abstract

Abstract Background Cerebral small vessel disease (CSVD) causes great disability at increasing age such as cognitive impairment, gait and sphincteric problems affecting a person’s quality of life. That is why it’s important to detect and manage early. The aim of this study is to investigate certain micro-RNA in Egyptian patients with CSVD. Methods Thirty patients with CSVD were compared to thirty controls undergoing assessment for cognitive, gait and sphincteric control together with MRI brain and blood sampling for miRNA (miR-409-3p, miR-502-3p, miR-486-5p and miR-451a). Results No difference regarding age, gender or risk factors, yet MiRNA-451a was up-regulated in cases with a median fold change of 3.4 in comparison to healthy controls. Conclusion The studied microRNA can may have a role in pathophysiology of CSVD.