review · RSC Advances
Metal-organic frameworks, composed of metal ions linked with organic ligands, are porous materials gaining interest for drug delivery and personalised medicine. Synthesising these materials allows customisation of critical properties such as surface area and pore dimensions. Encapsulating therapeutics within these porous structures improves drug stability and solubility, whilst providing controlled release kinetics that can enhance treatment efficacy and reduce unwanted side effects. Despite these benefits, several obstacles must be addressed before widespread adoption, notably material stability, biocompatibility, and manufacturing at scale. Continued progress in synthesis methods, functionalisation approaches, and a deeper grasp of how these frameworks interact with biological systems will be required to harness their potential for targeted medical therapies and improved patient outcomes.
Conventional medications often suffer from poor solubility, instability, and unintended side effects. Porous metal-organic frameworks offer a method to safeguard and deliver therapeutic molecules to patients in a controlled manner. Solving ongoing challenges around biocompatibility and large-scale manufacturing could significantly advance personalised medicine, resulting in safer and more effective treatment options.
This technology points toward therapeutic delivery systems for pharmaceutical developers focusing on personalised medicine. The abstract indicates early-stage research, as fundamental hurdles including biological compatibility, framework stability, and industrial scale-up production must be resolved before these materials can progress towards practical pharmaceutical manufacturing and clinical use.
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Recently, metal-organic frameworks (MOFs) have attracted much attention as versatile materials for drug delivery and personalized medicine. MOFs are porous structures made up of metal ions coupled with organic ligands. This review highlights the synthesis techniques used to design MOFs with specific features such as surface area and pore size, and the drug encapsulation within MOFs not only improves their stability and solubility but also allows for controlled release kinetics, which improves therapeutic efficacy and minimizes adverse effects. Furthermore, it discusses the challenges and potential advantages of MOF-based drug delivery, such as MOF stability, biocompatibility, and scale-up production. With further advancements in MOF synthesis, functionalization techniques, and understanding of their interactions using biological systems, MOFs can have significant promise for expanding the area of personalized medicine and improving patient outcomes.
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DOI: 10.1039/d4ra04441j
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