article · Biomaterials Science

Metal–organic framework MIL-101(Fe) functionalized with folic acid as a multifunctional nanocarrier for targeted chemotherapy–photodynamic therapy

202516 citationsOpen accessEgypt-Japan University of Science and Technology

Abstract

doses under both dark and light conditions indicates that the primary mechanism of cell death is necrosis, likely due to the enhanced formation of reactive oxygen species (ROS) under light conditions compared to that under dark conditions. This increased reactive oxygen species (ROS) generation leads to extensive membrane rupture, resulting in significant cell damage after treatment with the modified MIL-101-FA@50% DO8 NPs. These findings underscore the potential of this nanocomposite as an effective PDT agent for targeted cancer therapy.

Research topics

Metal-Organic Frameworks: Synthesis and Applications
Nanoplatforms for cancer theranostics
Advanced Photocatalysis Techniques

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DOI: 10.1039/d4bm01738b

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