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article · European Journal of Organic Chemistry

Metal‐ and Catalyst‐Free Synthesis of 2‐Substituted‐Phthalimides Using 2‐(Arenesulfonyl)Phthalimide as Key Reagents

Abstract

Abstract Phthalimide derivatives are important in medicinal chemistry, several phthalimidation methodologies have been developed. Here, we report a facile, metal‐free, and catalyst‐free method for the preparation of N ‐phthalimides in good to excellent yield by reacting 2‐(arenesulfonyl)phthalimides with various amine substrates.

Research topics

  • Synthesis and Catalytic Reactions
  • Catalytic C–H Functionalization Methods
  • Phenothiazines and Benzothiazines Synthesis and Activities

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DOI: 10.1002/ejoc.202300207

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