article · RSC Advances
This study aimed to discover the potential of <i>Medicago sativa</i>-derived fungal endophytes as a prospective source of bioactive metabolites. In the present study, three different strains of fungal endophyte <i>Aspergillus terreus</i> were isolated from leaves L, roots T and stems St of <i>Medicago sativa</i> to explore their biological and chemical diversity. These isolated fungi were exposed to different fermentation conditions by adding various chemical elicitors to their solid fermentation media. According to LC-HRESIMS-based metabolomics and multivariate analysis, each chemical treatment had a different effect on the chemical profiles of the fungi. Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) proposed several compounds with anticancer action against MCF-7 (a human breast cancer cell line) and MDA-MB-231 (a human epithelial breast cancer cell line).
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DOI: 10.1039/d4ra00790e
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