review · Medicine
Microbiota modulation involves intentionally altering the composition and activity of the microbial community to address various health conditions. A review of these approaches highlights their underlying mechanisms and practical uses across human health, healthcare delivery, and pharmacotherapy. Key intervention strategies encompass dietary adjustments, faecal microbiota transplantation, antibiotic administration, bacteriophage therapies, microbiome engineering, and targeted modulation of the immune system. These approaches demonstrate practical utility, particularly in addressing gastrointestinal disorders and immune-mediated diseases. Moving these researched concepts into routine clinical practice presents notable challenges, particularly regarding patient safety. Overcoming these barriers requires sustained investigation to establish reliable protocols, guiding future research directions in this rapidly developing area.
Understanding how to deliberately adjust the body's microbial populations opens new avenues for managing complex illnesses. By surveying methods ranging from dietary changes to biological therapies, this work clarifies how microbial interventions could treat gastrointestinal and immune conditions, while highlighting the safety standards required before widespread medical adoption.
The abstract highlights therapeutic opportunities in gastrointestinal and immune-mediated diseases using interventions such as microbiome engineering, bacteriophages, and faecal transplants. Prospective end users are clinicians, healthcare managers, and pharmacotherapy developers. Because this is a broad review outlining research translation challenges and safety concerns, the technologies span from early-stage concepts to emerging clinical interventions requiring further translational validation.
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Microbiota modulation, the intentional change in the structure and function of the microbial community, is an emerging trajectory that holds the promise to mitigate an infinite number of health issues. The present review illustrates the underlying principles of microbiota modulation and the various applications of this fundamental process to human health, healthcare management, and pharmacologic interventions. Different strategies, directing on dietary interventions, fecal microbiota transplantation, treatment with antibiotics, bacteriophages, microbiome engineering, and modulation of the immune system, are described in detail. This therapeutic implication is reflected in clinical applications to gastrointestinal disorders and immune-mediated diseases for microbiota-modulating agents. In addition to this, the review outlines the challenges of translating researched outcomes into clinical practice to consider safety and provides insights into future research directions of this rapidly developing area.
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DOI: 10.1097/md.0000000000038088
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