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article · Journal of Experimental Pharmacology

Mangiferin Mitigates Ketamine-Induced Dopaminergic and Glial Dysregulation and Modulates Nrf2 Expression in a Rat Schizophrenia-Like Model

2026Open accessUniversity of Nigeria

Abstract

These findings indicate that mangiferin attenuates ketamine-induced behavioral, oxidative, inflammatory, and glial alterations in motor-cognitive circuits and are consistent with modulation of redox-glial interactions, including Nrf2-associated antioxidant signaling. Collectively, the results support further evaluation of mangiferin and related Nrf2-modulating natural products as adjunctive strategies targeting redox-glial dysfunction in schizophrenia.

Research topics

  • Mangiferin and Mango Extracts
  • Adipokines, Inflammation, and Metabolic Diseases
  • Tryptophan and brain disorders

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DOI: 10.2147/jep.s589790

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