article · Scientia Africana
This study aims to investigate the in vitro antimicrobial interactions between crude aqueous extract of Azadirachta indica and standard antibiotics, including ciprofloxacin, and norfloxacin. Using checkerboard techniques with Bacillus subtilis as the test microorganism, the synergistic effect of Azadirachta indica and antibiotics (ciprofloxacin and norfloxacin), was determined. The checkerboard assay presented FIC indices indicative of synergy, particularly notable with the combination of A. indica extract and the antibiotics. Specifically, with the 4:6, 8:2, and 9:1 ratios of ciprofloxacin and 1.9 to 9:1 of norfloxacin. These results suggest a potentiation of antibacterial effects when the plant extract is used in conjunction with conventional antibiotics. The synergistic interaction could potentially reduce the required doses of antibiotics, thereby minimizing side effects and the risk of antibiotic resistance.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.4314/sa.v23i3.21
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
