article · BMC Research Notes
This research evaluates the safety and physiological effects of the probiotic Yoba on male fruit flies, Drosophila melanogaster. Flies were fed diets containing Yoba at concentrations of 1%, 3%, 6%, and 12% to assess motor function, total protein, catalase activity, hydrogen peroxide scavenging capacity, and overall lifespan. High concentrations of 6% or more increased locomotor activity in the flies. However, a lower concentration of 1% yielded significantly higher total protein levels, catalase activity, and antioxidant scavenging capacity than higher doses. Overall, the lowest concentration tested produced the greatest physiological benefits, while higher doses disrupted physiological function. These findings support the safety and suitability of using 1% probiotic formulations.
Probiotics are widely promoted for health, but determining safe and effective intake levels is critical. By demonstrating that a low dose provides antioxidant and physiological benefits while higher doses cause disruptions, this work helps validate dosage recommendations and prevents potential health risks associated with overconsumption.
The findings support the dosage rationale for probiotic food products promoted by initiatives like the Yoba for Life consortium. This early-stage research provides safety and biochemical evidence that probiotic developers and functional food producers can use to justify 1% formulations, though direct human validation remains necessary before moving beyond existing consumer programmes.
AI-generated from the published abstract. Always read the original work before citing.
The purpose of the study was to generate information on the safety of probiotics, thus the study objectives were to evaluate the effects of Yoba® on basic physiochemical properties. The study assessed male w1118 Drosophila melanogaster which were provided food supplemented with Yoba® at 1%, 3%, 6%, and 12% on motor function, total protein, catalase activity, and hydrogen peroxide scavenging activity and lifespan. Yoba® at high concentration (≥ 6%) increased locomotor activity in Drosophila melanogaster, however, total protein, catalase, and hydrogen peroxide scavenging activity were significantly higher at 1% Yoba® compared to 3%, 6%, and 12% Yoba®. Yoba consumed at 1% was associated with greater physiological benefits in Drosophila melanogaster. Findings in the study offer a rationale for the consumption of Yoba® at 1% in humans as is currently being promoted by the Yoba for Life consortium, however, high concentrations of Yoba® would disrupt physiological function as shown by this study.
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DOI: 10.1186/s13104-019-4297-x
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