article · Frontiers in Molecular Biosciences

LncRNA ILF3AS1, MMP3, and MMP9 as well as miRNA-212 as emerging novel biomarkers for childhood epilepsy

Amena Rezk Mohammed
Aya Ghamry
Aliaa A. Mosa
Alshaymaa A. Abd Elalim
Marwa A. Sabet
Marwa G. Gamea
Marwa K. Khairallah
Salwa Seif Eldin
Wafaa Emam
Eatemad Nabil Mansour
Rasha Sobhy Elattar
Haidy Mahmoud Nasr
Yasser G. Abish
Sabah M. Alkhawagah
Boshra Ahmed Zaghloul
Amal Fahmy Dawood
Doaa Sadek Ahmed Fathy
Shaymaa A. Mohammed
Suzan Eid Elshishtawy Ibrahim
Abdullah Hussein
Norah Alharbi
Marwa A. Dahpy

2024Open accessAin Shams University

Abstract

Serum levels of the lncRNA ILF3AS1 among children with epilepsy were higher than those in the control group and were associated with upregulation of both MMP3 and MMP9 as well as downregulation of miRNA-212 expressions, suggesting their predictive utility in monitoring the development of epilepsy; this also means that a treatment plan focusing on the ILF3AS1/miRNA-212/MMP3/MMP9 axis could be an effective strategy for treating epilepsy.

Research topics

Cancer-related molecular mechanisms research
RNA modifications and cancer
MicroRNA in disease regulation

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.3389/fmolb.2024.1434023

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