Janus Nanoparticles Loaded 3D Bio Printed Scaffold as a Dual Drug Delivery System

Abstract

Herein, a new type of controlled-release system is fabricated using polycaprolactone (PCL) and poly(lactic-co-glycolic acid) (PLGA) nanoparticles for the creation preparation study. They include doxorubicin (DOX), a standard chemical for chemotherapy, and curcumin, part of the plant turmeric. The material is produced as a dual-loaded nanoparticle system, where the widely used chemotherapeutic drug Doxorubicin (DOX) and the commonly known anti-inflammatory/antioxidant Curcumin are encapsulated in their respective phases, PCL and PLGA. Next, the Janus NPs were loaded into a 3D bioprinted support matrix composed solely of Carbopol. The design of this scaffold was engineered to provide a biocompatible and supportive environment for the controlled release of medication over an extended period. The biocompatibility, kinetics of drug release, and biomechanical properties were also analyzed in the 3D-printed scaffold. The structural integrity of the scaffold was strengthened, and DOX as well as curcumin can be continuously released for long periods by using Janus nanoparticles. Moreover, dual drug-loaded nanoparticles provided a sustained release plan that could be an innovative technique for improved anticancer activity in synergy therapy; the scaffold supported particle stability as indicated by favorable results of preliminary research. This system might offer a more potent and target-oriented strategy in cancer therapy through the sustained release of curcumin and DOX, effectively reducing cancer cell viability compared to conventional drug delivery approaches.