JAK2 and PTPRC mRNA Expression Levels in Ankylosing Spondylitis and Systemic Lupus Erythematosus Patients

Abstract

Objectives: to evaluate RNA expression levels of Janus Kinase 2 (JAK 2) and protein tyrosine phosphatase receptor type C (PTPRC) genes in SLE and AS and correlate them with the severity of the two diseases. Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder with a wide range of clinical symptoms. Ankylosing spondylitis (AS) is an autoimmune inflammatory disease of young adult, affecting the axial skeleton and articular joints. Methods: A case-control study included 96 subjects: (32 SLE patients, 32 AS patients, and 32 healthy control subjects). Differences in the expression levels of JAK2 and PTPRC in the blood of AS and SLE patients were tested using quantitative real-time PCR (qRT-PCR). Results: Expression levels of JAK2 mRNA increased significantly (P