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article · Pacing and Clinical Electrophysiology

Ion channel dysfunction and fibrosis in atrial fibrillation: Two sides of the same coin

202421 citationsAssiut University

Abstract

Understanding the role of fibrosis in genetic determined AF could be important to better comprise the pathophysiology of this arrhythmia and to refine its management also in nongenetic forms. In this review we analyze genetic and epigenetic mechanisms responsible for AF and their link with atrial fibrosis, then we will consider analogies with the pathophysiological mechanism in nongenetic AF, and discuss consequent therapeutic options.

Research topics

  • Atrial Fibrillation Management and Outcomes
  • Cardiac electrophysiology and arrhythmias
  • Cardiac Arrhythmias and Treatments

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DOI: 10.1111/pace.14944

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