Intra-Ovarian Platelet-Rich Plasma (PRP) Injection in Management of POSEIDON IV Poor Responders before ICSI: Pilot Study

Abstract

Abstract Background Poseidon IV poor responders are 35 years old or older women with antral follicle count < 5 and anti-Mullerian hormone < 1.2 ng/ml with cumulative live birth rate (CLBR) of 22.34% - 34.46% following ICSI. Aim of the Work To assess the effectiveness of intra-ovarian platelet-rich plasma (PRP) injection in POSEIDON IV poor responders before ICSI. Patients and Methods This study was conducted on women complaining from infertility at assisted reproductive techniques unit at Ain Shams University Maternity Hospital at the period from March 2021 till January 2022. We got a 55 cases matching the inclusion and exclusion criteria among them 25 cases accepted to participate as the study group (PRP group) and the others 30 cases refused to the participate PRP group and they were enrolled as a control group. Results Endometrium thickness at day of HCG trigger was statistically significantly higher among PRP group than among control group. Ovulation statistically was non-significantly more frequent among PRP group than among control group. Fertilization statistically was non- significantly more frequent among PRP group than among control group. biochemical pregnancy, clinical pregnancy, ongoing pregnancy statistically were non-significantly more frequent among PRP group than among control group. Conclusion According to the finding in this study intra-ovarian platelet-rich plasma (PRP) injection in POSEIDON IV poor responders before ICSI had a non-significant role regarding the laboratory variables and pregnancy outcomes. Hence, further studies are required.